SP140 inhibitor suppressing TRIM22 expression regulates glioma progress through PI3K/AKT signaling pathway
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View abstract on PubMed
Summary
This summary is machine-generated.The SP gene family, including SP140, is linked to glioma progression. A SP140 nomogram predicts survival, and its inhibitor suppresses glioma growth via the TRIM22/PI3K/AKT pathway.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- The SP gene family (SP100, SP110, SP140, SP140L) is implicated in various cancers.
- The clinical role of SP genes in glioma remains unclear.
Purpose Of The Study
- To investigate the expression and prognostic significance of SP family members in glioma.
- To develop and validate a SP140-based predictive model for glioma patient survival.
- To explore the therapeutic potential of SP140 inhibition in glioma.
Main Methods
- Analysis of SP gene expression and survival data in TCGA and CGGA datasets.
- Development and validation of a SP140-based nomogram using TCGA and CGGA data.
- In vitro studies using glioma cells to assess the effects of a SP140 inhibitor (GSK761) on cell behavior and signaling pathways.
Main Results
- SP family members are upregulated in gliomas and associated with poor prognosis.
- SP140 is an independent prognostic factor, and the SP140 nomogram accurately predicts survival.
- SP140 inhibition suppressed glioma proliferation, migration, and invasion by downregulating TRIM22 and the PI3K/AKT pathway.
Conclusions
- A SP140-based nomogram is a valuable tool for predicting glioma patient survival.
- SP140 inhibition offers a potential therapeutic strategy for glioma by targeting the TRIM22/PI3K/AKT pathway.
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