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Updated: Jun 24, 2026

Murine Colitis Modeling using Dextran Sulfate Sodium DSS
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Murine Colitis Modeling using Dextran Sulfate Sodium DSS

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Bovine Milk Derived Exosomes Affect Gut Microbiota of DSS-Induced Colitis Mice

Tonghao Li1, Xiaolin Chen1, Qien Qi1

  • 1School of Life Science and Engineering, Foshan University, No. 33 Guangyun Road, Nanhai District, Foshan, Guangdong China.

Indian Journal of Microbiology
|March 12, 2024
PubMed

Insights

Bovine milk derived exosomes (MDEs) positively impacted the gut microbiota in mice with Dextran sodium sulfate (DSS)-induced colitis. MDEs helped maintain microbial diversity and altered specific bacterial populations, suggesting potential therapeutic benefits for colitis.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Biotechnology

Background:

  • Inflammatory bowel disease, including colitis, is a significant health concern.
  • Gut microbiota dysbiosis plays a crucial role in the pathogenesis of colitis.
  • Exosomes derived from bovine milk (MDEs) are being explored for their therapeutic potential.

Purpose of the Study:

  • To investigate the effects of MDEs on the gut microbiota composition in a mouse model of DSS-induced colitis.
  • To evaluate the potential of MDEs in mitigating gut dysbiosis associated with colitis.

Main Methods:

  • Utilized a Dextran sodium sulfate (DSS)-induced colitis mouse model.
  • Administered MDEs orally to the treatment group.
  • Analyzed gut microbiota composition using 16S rRNA gene sequencing of cecal digesta.

Main Results:

  • DSS-induced colitis significantly reduced feed intake and gut microbial diversity (Shannon index).
  • MDE administration did not significantly alter feed intake or Shannon index compared to controls.
  • MDEs tended to increase the relative abundance of *Campylobaterota* and *Lachnospiraceae_UCG_006*.

Conclusions:

  • Oral MDE administration positively modulated the gut microbiota in DSS-induced colitis mice.
  • MDEs showed a tendency to restore certain bacterial populations altered by DSS.
  • These findings suggest MDEs hold promise for the prevention and treatment of colitis.
Keywords:
Bovine milk derived exosomesColitis mouseDextran sodium sulfateMicrobiota

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