Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

493
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
493
Glaucoma: Overview01:25

Glaucoma: Overview

570
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
570
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

448
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
448

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PANoptosis-Related Diagnostic Biomarkers in Non-Neovascular Age-Related Macular Degeneration: An Integrative Transcriptomic and Experimental Study.

Genetics research·2026
Same author

Systematic review and sequential analysis of traditional Chinese medicine in the treatment of age-related macular degeneration based on GRADE evidence quality rating.

Medicine·2025
Same author

Application of artificial intelligence for automatic cataract staging based on anterior segment images: comparing automatic segmentation approaches to manual segmentation.

Frontiers in neuroscience·2023
Same author

Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.

Journal of medicinal chemistry·2013
Same author

Sequential [3 + 2] and [4 + 2] cycloadditions for stereoselective synthesis of a novel polyheterocyclic scaffold.

ACS combinatorial science·2013
Same author

VEGF-c expression in an in vivo model of orthotopic endometrial cancer and retroperitoneal lymph node metastasis.

Reproductive biology and endocrinology : RB&E·2013
Same journal

Discontinuing Anti-VEGF Therapy in Patients with Neovascular Age-Related Macular Degeneration That Remains Inactive with Treatment at the Maximum Injection Interval.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same journal

Ophthalmic Implications of Ehlers-Danlos Syndrome.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same journal

Diagnostic Value of Pupil Involvement and Yield of Vascular Imaging in Isolated Third Cranial Nerve Palsy: A 10-Year Retrospective Study.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same journal

Short-Term Preliminary Results of Outcomes with and without Tenonectomy During Open Conjunctival XEN45 Gel Stent Implantation.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same journal

Chemical and Thermal Ocular Burns in Children: A Retrospective Single-Center Study of Etiology, Clinical Characteristics, and Outcomes.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same journal

Two-Year Follow-Up of the MINI WELL Non-Diffractive Extended Depth-of-Focus Intraocular Lens: A Retrospective Observational Study.

Clinical ophthalmology (Auckland, N.Z.)·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2025

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping
07:11

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping

Published on: December 8, 2023

1.5K

Machine Learning Analysis Classifies Patients with Primary Angle-Closure Glaucoma Using Abnormal Brain White Matter

Qiu-Yu Tang1, Yu-Lin Zhong2, Xin-Miao Wang3

  • 1College of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi, 330004, People's Republic of China.

Clinical Ophthalmology (Auckland, N.Z.)
|March 12, 2024
PubMed
Summary
This summary is machine-generated.

Primary angle-closure glaucoma (PACG) is linked to white matter (WM) function changes in vision-related brain regions. This study reveals abnormal WM alterations in PACG patients, offering new insights into brain damage.

Keywords:
amplitude of low frequency fluctuationsprimary angle-closure glaucomasupport vector machinewhite matter

More Related Videos

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.4K
Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software
08:57

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Published on: September 4, 2021

4.0K

Related Experiment Videos

Last Updated: Jul 1, 2025

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping
07:11

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping

Published on: December 8, 2023

1.5K
Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

6.4K
Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software
08:57

Quantification of Optic Nerve Cross Sectional Area on MRI: A Novel Protocol using Fiji Software

Published on: September 4, 2021

4.0K

Area of Science:

  • Neuroimaging
  • Ophthalmology
  • Neurology

Background:

  • Primary angle-closure glaucoma (PACG) is a leading cause of irreversible blindness worldwide.
  • Previous studies linked PACG to gray matter functional changes.
  • White matter (WM) function in PACG remains largely unexplored.

Purpose of the Study:

  • To investigate white matter (WM) function changes in patients with primary angle-closure glaucoma (PACG).

Main Methods:

  • Resting-state functional magnetic resonance imaging (rs-fMRI) was used in 40 PACG patients and 40 healthy controls (HC).
  • Amplitude of low-frequency fluctuations (ALFF) was employed to compare WM function between groups.
  • Support Vector Machine (SVM) was utilized for PACG classification.

Main Results:

  • ALFF was significantly attenuated in the right posterior thalamic radiation, splenium of the corpus callosum, and left tapetum in PACG patients compared to HC.
  • Statistical significance was confirmed using GRF correction (voxel-level P < 0.001, cluster-level P < 0.05).
  • The SVM model achieved 80.0% accuracy and an AUC of 0.86 in distinguishing PACG patients from HC.

Conclusions:

  • This study identifies abnormal WM functional alterations in PACG, primarily in vision-related areas.
  • Findings suggest widespread brain damage in PACG from a WM functional perspective.
  • These results provide novel insights into the neurological underpinnings of PACG.