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Updated: Jul 1, 2025

Electrophysiological Measurements and Analysis of Nociception in Human Infants
Published on: December 20, 2011
The Effect of a Combination of Vibration and External Cold on Pain Caused during Vaccine Injection in Infants: A
Zahra Unesi1, Zahra Amouzeshi2, Javad Jamavar3
1Faculty of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, Iran.
Insights
Combining vibration and cold significantly reduced pain and crying duration in infants during vaccine injections. This non-pharmacological method offers a simple solution for pain management in vaccination settings.
Area of Science:
- Pediatrics
- Pain Management
- Clinical Trials
Background:
- Infant vaccination is associated with pain and distress.
- Effective pain management strategies are crucial for infant well-being during immunizations.
Purpose of the Study:
- To evaluate the efficacy of combining vibration and external cold in alleviating pain during vaccine injections in six-month-old infants.
Main Methods:
- A randomized controlled trial involving 80 infants.
- The intervention group received a vibrating and cold device during pentavalent vaccine injection.
- The control group received standard vaccination procedures.
Main Results:
- Infants in the intervention group experienced significantly lower mean pain intensity (p=0.032) and crying duration (p=0.0001).
- Mean pain intensity was 6.1 ± 1.8 in the intervention group versus 7.2 ± 0.1 in the control group.
- Mean crying duration was 32.47 ± 16.78 seconds in the intervention group versus 51.02 ± 25.9 seconds in the control group.
Conclusions:
- The combination of vibration and cold is an effective non-pharmacological method for reducing pain in infants during vaccination.
- Healthcare providers can utilize this simple intervention to improve the vaccination experience for infants and reduce crying time.
Aim:
This study was conducted to determine the effect of combining vibration and external cold on pain caused by vaccine injection among six-month-old infants.
Design:
Randomized controlled trial.
Methods:
In this clinical trial, 80 eligible infants were selected from the infants referred to a health center as per the inclusion criteria. The infants were assigned to either a control group or an intervention group by block randomization. In the intervention group, a vibrating and cold device was placed above the injection site from one minute before to 15 seconds after the pentavalent vaccine injection. In the control group, no intervention was performed, and they were vaccinated according to the routine procedure. The pain status in the two groups was measured using the Modified Behavioral Pain Scale (MBPS) 15 seconds after the injection, and the crying duration was assessed from the injection of the vaccine till the end of it. Data were analyzed in SPSS 23 software using Mann-Whitney, t, Spearman, and chi-square tests. The level of significance was set to p < 0.05.
Results:
Most participants in the control (55%) and intervention (55%) groups were girls. Statistical data analysis of 80 infants showed that the mean pain intensity (p = 0.032) and duration of crying (p = 0.0001) in the intervention group (6.1 ± 1.8, 32.47 ± 16.78) were lower than those of the control group (7.2 ± 0.1, 51.02 ± 25.9), respectively.
Conclusion:
Because the intensity of pain, especially the duration of crying, was lower in the intervention group than in the control group, we may suggest that nurses use simple pain relief solutions in vaccination centers, such as a combination of vibration and cold. This trial is registered with IRCT201207157130N2.
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