Highly-ordered assembled organic fluorescent materials for high-resolution bio-sensing: a review

Area of Science:

• Materials Science
• Biotechnology
• Analytical Chemistry

Background:

• Organic fluorescent materials (OFMs) are vital for biosensors, enabling biochemical analysis in biological systems.
• Current OFM biosensors face limitations in resolution, dispersivity, and stability, hindering practical applications.

Purpose of the Study:

• To review highly-ordered assembled OFMs for biosensor applications.
• To discuss assembly interactions and applications of these advanced OFM biosensors.
• To provide insights into future trends and overcome current limitations.

Main Methods:

• Review of literature on highly-ordered assembled OFMs.
• Analysis of assembly interactions (hydrogen bonding, π-π, dipole-dipole, ion electrostatic).
• Evaluation of biosensor applications and limitations.

Main Results:

• Highly-ordered assembled OFMs offer improved anti-diffusion, imaging contrast, and stability compared to conventional OFMs.
• These materials are effective for bio-signal tracking, particularly for non-invasive chronic disease monitoring.
• Various intermolecular interactions drive the assembly of OFMs.

Conclusions:

• Highly-ordered assembled OFMs present a promising strategy to enhance biosensor performance and overcome existing challenges.
• Further research and development are needed to address limitations for commercialization.
• These advanced materials offer significant potential for future biosensing technologies and medical diagnostics.