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Risks of glaucoma among individuals with psoriasis: a population-based cohort study.

Shu-Hao Li¹, Chun-Yu Cheng^1,2,3

¹Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Clinical and Experimental Dermatology

|March 12, 2024

Summary

Patients with psoriasis face a higher risk of developing glaucoma. Long-term psoralen-ultraviolet A (PUVA) therapy further increases this risk, highlighting the need for vigilant eye monitoring.

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Area of Science:

Ophthalmology
Dermatology
Systemic Autoimmune Diseases

Background:

Psoriasis is a chronic inflammatory condition with known systemic implications.
Ocular manifestations are increasingly recognized in patients with psoriasis.

Purpose of the Study:

To investigate the association between psoriasis and the subsequent risk of glaucoma.
To explore the impact of specific psoriasis treatments on glaucoma risk.

Main Methods:

A large-scale cohort study utilizing the Chang Gung Research Database (2003-2012).
Matched controls (1:4 ratio) were used for comparison.
Cox regression analysis estimated hazard ratios for glaucoma.
Evaluated risks associated with systemic therapies, phototherapy, and topical corticosteroids.

Main Results:

6,682 psoriasis patients and 26,728 controls were analyzed.
Psoriasis patients exhibited a significantly higher incidence rate of glaucoma (aHR 1.405).
Psoralen-ultraviolet A (PUVA) therapy exceeding 200 sessions correlated with elevated glaucoma risk.

Conclusions:

Individuals diagnosed with psoriasis demonstrate an increased risk of developing glaucoma.
Prolonged exposure to PUVA therapy is a significant risk factor for glaucoma in psoriasis patients.