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Updated: Jul 1, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

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Risks of glaucoma among individuals with psoriasis: a population-based cohort study

Shu-Hao Li1, Chun-Yu Cheng1,2,3

  • 1Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Clinical and Experimental Dermatology
|March 12, 2024
PubMed

Insights

Patients with psoriasis face a higher risk of developing glaucoma. Long-term psoralen-ultraviolet A (PUVA) therapy further increases this risk, highlighting the need for vigilant eye monitoring.

Area of Science:

  • Ophthalmology
  • Dermatology
  • Systemic Autoimmune Diseases

Background:

  • Psoriasis is a chronic inflammatory condition with known systemic implications.
  • Ocular manifestations are increasingly recognized in patients with psoriasis.

Purpose of the Study:

  • To investigate the association between psoriasis and the subsequent risk of glaucoma.
  • To explore the impact of specific psoriasis treatments on glaucoma risk.

Main Methods:

  • A large-scale cohort study utilizing the Chang Gung Research Database (2003-2012).
  • Matched controls (1:4 ratio) were used for comparison.
  • Cox regression analysis estimated hazard ratios for glaucoma.
  • Evaluated risks associated with systemic therapies, phototherapy, and topical corticosteroids.

Main Results:

  • 6,682 psoriasis patients and 26,728 controls were analyzed.
  • Psoriasis patients exhibited a significantly higher incidence rate of glaucoma (aHR 1.405).
  • Psoralen-ultraviolet A (PUVA) therapy exceeding 200 sessions correlated with elevated glaucoma risk.

Conclusions:

  • Individuals diagnosed with psoriasis demonstrate an increased risk of developing glaucoma.
  • Prolonged exposure to PUVA therapy is a significant risk factor for glaucoma in psoriasis patients.
Abstract

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