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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
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Risks of glaucoma among individuals with psoriasis: a population-based cohort study
Shu-Hao Li1, Chun-Yu Cheng1,2,3
1Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Clinical and Experimental Dermatology
|March 12, 2024
Summary
Patients with psoriasis face a higher risk of developing glaucoma. Long-term psoralen-ultraviolet A (PUVA) therapy further increases this risk, highlighting the need for vigilant eye monitoring.
Area of Science:
- Ophthalmology
- Dermatology
- Systemic Autoimmune Diseases
Background:
- Psoriasis is a chronic inflammatory condition with known systemic implications.
- Ocular manifestations are increasingly recognized in patients with psoriasis.
Purpose of the Study:
- To investigate the association between psoriasis and the subsequent risk of glaucoma.
- To explore the impact of specific psoriasis treatments on glaucoma risk.
Main Methods:
- A large-scale cohort study utilizing the Chang Gung Research Database (2003-2012).
- Matched controls (1:4 ratio) were used for comparison.
- Cox regression analysis estimated hazard ratios for glaucoma.
- Evaluated risks associated with systemic therapies, phototherapy, and topical corticosteroids.
Main Results:
- 6,682 psoriasis patients and 26,728 controls were analyzed.
- Psoriasis patients exhibited a significantly higher incidence rate of glaucoma (aHR 1.405).
- Psoralen-ultraviolet A (PUVA) therapy exceeding 200 sessions correlated with elevated glaucoma risk.
Conclusions:
- Individuals diagnosed with psoriasis demonstrate an increased risk of developing glaucoma.
- Prolonged exposure to PUVA therapy is a significant risk factor for glaucoma in psoriasis patients.
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