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Interaction Between Microbubbles and Microwave Ablation: A Phantom and Rabbit Model.

Xinyu Zhong1, Xinghao Zhang1, Yuting Cao2

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Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
|March 12, 2024
PubMed
Summary
This summary is machine-generated.

Microbubbles do not significantly affect microwave ablation (MWA) outcomes or temperature increases. However, MWA destroys microbubbles in a temperature-dependent way, limiting their use for real-time monitoring.

Keywords:
contrast‐enhanced ultrasoundimaging monitoringmicrobubblesmicrowave ablationphantomsultrasound

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Area of Science:

  • Medical Imaging and Interventional Radiology
  • Biophysics of Ultrasound and Thermal Ablation

Background:

  • Microwave ablation (MWA) is a minimally invasive thermal ablation technique.
  • Microbubbles are used as contrast agents in ultrasound imaging, including contrast-enhanced ultrasound (CEUS).
  • Understanding the interaction between microbubbles and MWA is crucial for potential real-time monitoring applications.

Purpose of the Study:

  • To investigate the interactions between microbubbles and microwave ablation (MWA).
  • To evaluate the effect of microbubbles on MWA parameters and outcomes.
  • To assess the feasibility of using microbubbles for real-time monitoring of MWA.

Main Methods:

  • In vitro studies using custom-made phantoms and in vivo studies using rabbit livers.
  • MWA performed with and without microbubbles (SonoVue) in phantoms and rabbit livers.
  • Temperature monitoring using K-type thermocouple probes and microbubble signal intensity analysis using CEUS.

Main Results:

  • Microbubbles did not significantly alter MWA-induced temperature increases or ablation ranges in phantoms or rabbit livers.
  • MWA led to the formation of a microbubble-defect region, which expanded with ablation time.
  • Increased temperatures caused microbubble destruction in a temperature-dependent manner.

Conclusions:

  • Microbubbles do not significantly influence the efficacy of MWA.
  • The temperature-dependent destruction of microbubbles by MWA presents a limitation for using CEUS for real-time ablation monitoring.
  • The poor thermotolerance of microbubbles is a key consideration for their application in conjunction with MWA.