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Reporter Genes02:11

Reporter Genes

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Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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Incomplete Dominance01:43

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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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How Do I Report Genes in a Paper?

Carolin Gabbert1, Christine Klein1, Joanne Trinh1

  • 1Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

Movement Disorders Clinical Practice
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PubMed
Summary
This summary is machine-generated.

Genetic testing advances rapidly, increasing identified genes and variants. This tutorial guides researchers on reporting gene information and handling novel gene discoveries using available databases and tools.

Keywords:
clinical significancegenenomenclaturepathogenicitytranscripts

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Area of Science:

  • Genetics
  • Bioinformatics
  • Genomic Medicine

Background:

  • Next-generation sequencing technologies have significantly advanced genetic testing capabilities.
  • The increasing volume of identified genes and genetic variants necessitates standardized reporting practices.
  • Existing databases and tools offer valuable information but lack comprehensive guidelines for gene reporting.

Purpose of the Study:

  • To provide a tutorial for researchers on reporting genes in scientific publications.
  • To outline essential information required when reporting genes, including nomenclature, loci, variation, aliases, and phenotypes.
  • To introduce available databases and tools for acquiring necessary gene information.

Main Methods:

  • Literature review of existing genetic databases and bioinformatics tools.
  • Synthesis of information regarding gene nomenclature and variant classification standards.
  • Development of a structured approach for reporting genetic findings.

Main Results:

  • Identification of a gap in current guidelines for reporting genetic information.
  • Compilation of key information categories essential for gene reporting.
  • Overview of relevant online resources for gene data retrieval.

Conclusions:

  • Standardized reporting of genetic information is crucial for scientific reproducibility and clarity.
  • Researchers can leverage existing databases and tools to effectively report gene discoveries.
  • This tutorial serves as an introductory resource for navigating gene information reporting.