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Summary

Göttingen pigs can be trained to perform a visual psychophysics test assessing contrast sensitivity. These animals can independently complete trials, aiding preclinical ophthalmology research.

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Area of Science:

  • Ophthalmology
  • Animal Models
  • Visual Science

Background:

  • Contrast sensitivity is crucial for assessing human visual function.
  • Large animal models are valuable for preclinical ophthalmology research, aiding drug development and efficacy studies.

Purpose of the Study:

  • To develop and validate a visual psychophysics test for assessing contrast sensitivity function in pigs.
  • To establish a reliable method for evaluating visual function in a large animal model.

Main Methods:

  • Utilized a touchscreen and pellet reward dispenser to train Göttingen pigs on a visual psychophysics test.
  • Employed images with varying contrast resolutions as visual stimuli in a two-choice test.
  • Enabled self-administered trials without human intervention after initial training and acclimatization.

Main Results:

  • All pigs were trained within one week and retained the task with minimal reinforcement.
  • Trained animals demonstrated proficient performance with minimal screen-side bias, particularly at contrast thresholds above 40%.

Conclusions:

  • Göttingen pigs are trainable for visual psychophysics testing.
  • Pigs can autonomously complete visual function assessment trials, supporting their use in preclinical research.