Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

2.0K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.0K
Anorexia Nervosa01:28

Anorexia Nervosa

64
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
64
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

1.4K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
1.4K
Metabolic States of the Body: The Postabsorptive State01:18

Metabolic States of the Body: The Postabsorptive State

312
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
312

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Incretin-Based and Nonpharmacologic Weight Loss on Body Composition : A Systematic Review.

Annals of internal medicine·2026
Same author

Stage of Disease Among Hospitalized Persons Living With Dementia: A Multisite Study.

Journal of the American Medical Directors Association·2026
Same author

EffectS of Lifestyle Interventions in Older PEople With Obesity (Effective SLOPE): a Systematic Review With Network Meta-Analyses.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2026
Same author

Perspectives of Older Adults and Their Caregivers on Post-Discharge Medication Management: A Qualitative Study.

Health science reports·2026
Same author

Reduced-exertion high-intensity interval training (REHIT) provides limited improvement in post-prandial and 24-hour glycemia in healthy, physically active men.

Journal of exercise science and fitness·2026
Same author

Identifying Older Adults at Risk of Accelerated Decline in Gait Speed and Grip Strength: Insights from the National Health and Aging Trends Study (NHATS).

Journal of ageing and longevity·2026

Related Experiment Video

Updated: Jul 1, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

16.6K

Changes in Weight or Body Composition by Frailty Status: A Pilot Study.

Hillary B Spangler1, David H Lynch1, Danae C Gross2

  • 1Division of Geriatric Medicine, UNC School of Medicine, Chapel Hill, North Carolina, USA.

Journal of Nutrition in Gerontology and Geriatrics
|March 12, 2024
PubMed
Summary

Older adults with obesity can safely lose weight using technology, regardless of their frailty status. This study found significant weight reduction in both frail and pre-frail individuals, indicating a safe approach for diverse aging populations.

Keywords:
Frailtyobesitytechnologyweight loss

More Related Videos

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
07:27

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

10.3K
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

523

Related Experiment Videos

Last Updated: Jul 1, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

16.6K
Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
07:27

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

10.3K
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

523

Area of Science:

  • Gerontology and Geriatric Medicine
  • Obesity Research
  • Health Technology

Background:

  • Weight loss interventions are crucial for older adults with obesity.
  • The impact of frailty status on weight loss outcomes in this demographic remains unclear.
  • Understanding frailty phenotypes is essential for tailoring effective health strategies.

Purpose of the Study:

  • To investigate whether different frailty phenotypes influence weight loss outcomes in older adults with obesity.
  • To assess the safety and efficacy of a technology-based weight loss program in community-dwelling older adults.
  • To compare changes in weight, lean mass, and fat-free mass between pre-frail and frail participants.

Main Methods:

  • Recruitment of 53 community-dwelling adults aged 65 and older with a body mass index of 30 kg/m² or higher.
  • A six-month, single-arm, technology-based weight loss intervention.
  • Frailty status determined at baseline using a 45-item frailty index with subjective and objective geriatric assessment measures.

Main Results:

  • At baseline, 41.5% were pre-frail (n=22) and 58.5% were frail (n=31), with no demographic differences.
  • Both pre-frail and frail groups achieved significant weight loss (p < 0.001).
  • No significant differences were observed between groups regarding changes in weight (p=0.30), appendicular lean mass/height² (p=0.47), or fat-free mass (p=0.06).

Conclusions:

  • A technology-based weight loss approach is safe for older adults with obesity, irrespective of their frailty status.
  • The study demonstrates that both pre-frail and frail older adults can achieve meaningful weight reduction.
  • Further research is warranted to explore differential effects of specific lifestyle interventions based on frailty status.