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Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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Obesity01:24

Obesity

498
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
498
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Metabolic Rate01:25

Metabolic Rate

384
The human body is a powerhouse of energy, with every cell performing numerous functions that require energy. This energy production and consumption is measured by the metabolic rate, which quantifies the total heat generated by all the body's chemical reactions and mechanical work. This measurement helps to determine the rate of kilocalorie (kcal) consumption needed to fuel all ongoing activities.
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...
384
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  9. Predictive And Prognostic Markers
  11. Are Higher Body Mass Index And Worse Metabolic Parameters Associated With More Aggressive Differentiated Thyroid Cancer? A Retrospective Cohort Study.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Are Higher Body Mass Index And Worse Metabolic Parameters Associated With More Aggressive Differentiated Thyroid Cancer? A Retrospective Cohort Study.

Related Experiment Video

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

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Are Higher Body Mass Index and Worse Metabolic Parameters Associated with More Aggressive Differentiated Thyroid Cancer? A Retrospective Cohort Study.

Yasmin Abu Arar1, Michael Shilo2, Natalya Bilenko2

  • 1Internal Medicine Ward D, Soroka University Medical Center, Beer-Sheva 84101, Israel.

Healthcare (Basel, Switzerland)
|March 12, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
PTC histological variantsbody mass index (BMI)differentiated thyroid cancer (DTC)metabolic syndrome

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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

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Related Experiment Videos

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Higher body mass index (BMI) and elevated triglycerides/high-density lipoprotein-cholesterol (TG/HDL-C) ratios are linked to more aggressive differentiated thyroid cancer (DTC) features, including lymph node metastasis and specific histological variants. This finding highlights metabolic factors in DTC progression.

Area of Science:

  • Endocrinology
  • Oncology
  • Metabolic Syndrome

Background:

  • Obesity is a known risk factor for differentiated thyroid cancer (DTC).
  • The relationship between obesity, metabolic parameters, and DTC aggressiveness remains debated.
  • Understanding these associations is crucial for predicting patient outcomes.

Purpose of the Study:

  • To investigate the association between preoperative body mass index (BMI) and other metabolic markers with the aggressiveness of differentiated thyroid cancer (DTC).
  • To analyze clinical and histopathological features of DTC in relation to patient metabolic status within a surgical cohort.

Main Methods:

  • Retrospective evaluation of 211 patients diagnosed with DTC between December 2013 and January 2021.
  • Analysis of baseline characteristics, histopathological data, treatment, and follow-up information.
obesity
papillary thyroid carcinoma (PTC)
triglycerides/high-density lipoprotein (HDL)–cholesterol ratio
  • Logistic regression modeling to assess the impact of BMI and metabolic parameters on adverse DTC features.

    • Main Results:

    • Higher BMI was associated with an increased risk of lymph node metastases (OR 1.077).
    • An elevated triglycerides/high-density lipoprotein-cholesterol (TG/HDL-C) ratio correlated with aggressive DTC histological variants (OR 1.269).
    • Patients with overweight or obesity underwent more complete thyroidectomies compared to normal-weight individuals.

    Conclusions:

    • Preoperative BMI and TG/HDL-C ratio are associated with adverse clinical and histopathological features in differentiated thyroid cancer.
    • Metabolic health indicators may play a role in the progression and characteristics of DTC.
    • Further research can explore targeted interventions based on these metabolic associations.