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TCMSSD: A comprehensive database focused on syndrome standardization.

Lin Huang1, Qiao Wang2, Qingchi Duan2

  • 1College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China; Key Laboratory of Chinese Medicine Rheumatology of Zhejiang Province, China.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|March 12, 2024
PubMed
Summary

The Traditional Chinese Medical Syndrome Standardization Database (TCMSSD) offers a comprehensive resource for Traditional Chinese Medicine (TCM) syndrome differentiation research. It integrates extensive data and employs advanced algorithms for accurate syndrome prediction.

Keywords:
BM25 algorithmDatabaseKnowledge graphSyndrome predictionTCM

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Area of Science:

  • Integrative Medicine
  • Computational Biology
  • Traditional Chinese Medicine

Background:

  • Standardized research on Traditional Chinese Medicine (TCM) syndrome differentiation is crucial for modernizing TCM theory.
  • Existing databases predominantly focus on network pharmacology of herbal prescriptions, with limited resources for TCM syndrome differentiation.

Purpose of the Study:

  • To address the gap in TCM syndrome differentiation resources, the Traditional Chinese Medical Syndrome Standardization Database (TCMSSD) was developed.
  • The TCMSSD aims to provide a centralized and standardized platform for TCM syndrome data.

Main Methods:

  • The TCMSSD database was constructed using data from TCM literature and public databases (TCMID, ETCM).
  • A deep learning approach was employed to build a knowledge graph for the database.
  • The BM25 algorithm was utilized for the syndrome prediction functionality.

Main Results:

  • The TCMSSD contains extensive data, including 624 syndromes, 133,518 prescriptions, 8,073 diseases, and 8,259 Chinese herbal medicines.
  • The database integrates information on 43,413 ingredients, 17,602 targets, and 8,182 drugs.
  • A syndrome prediction tool analyzes input data against the database to generate predictions based on established patterns.

Conclusions:

  • The TCMSSD successfully fills a critical gap by offering a comprehensive resource for quantitative and standardized TCM syndrome differentiation research.
  • This database lays the groundwork for future investigations into the biological underpinnings of TCM syndromes.