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Updated: Jul 1, 2025

Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
Targeting TRP channels for pain relief: A review of current evidence from bench to bedside
Ari-Pekka Koivisto1, Thomas Voets2, Michael J Iadarola3
1Pain Therapy Area, R&D, Orion Pharma Corporation, Turku, Finland.
Abstract:
Several decades of research support the involvement of transient receptor potential (TRP) channels in nociception. Despite the disappointments of early TRPV1 antagonist programs, the TRP family remains a promising therapeutic target in pain disorders. High-dose capsaicin patches are already in clinical use to relieve neuropathic pain. At present, localized injections of the side-directed TRPV1 agonist capsaicin and resiniferatoxin are undergoing clinical trials in patients with osteoarthritis and bone cancer pain. TRPA1, TRPM3, and TRPC5 channels are also of significant interest. This review discusses the role of TRP channels in human pain conditions.
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