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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Updated: Jul 1, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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Intraepithelial tumor-infiltrating lymphocytes shape loco-regional PET/CT spread of locally advanced cervical cancer.

Mathilde Del1, Claire Illac2, Mathilde Morisseau3

  • 1Department of Surgical Oncology, Institut Universitaire du Cancer Toulouse Oncopole, Toulouse, France mathilde.del@hotmail.com.

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
|March 12, 2024
PubMed
Summary
This summary is machine-generated.

Positron emission tomography/CT (PET/CT) metabolic metrics did not correlate with tumor-infiltrating lymphocytes in cervical cancer. However, low intraepithelial tumor-infiltrating lymphocytes indicated more advanced disease, and high stromal tumor-infiltrating lymphocytes correlated with pelvic lymph node involvement.

Keywords:
cervical cancerlymph nodes

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Area of Science:

  • Oncology
  • Immunology
  • Radiology

Background:

  • Positron emission tomography/computed tomography (PET/CT) metabolic metrics show potential in assessing tumor microenvironment and response to immunotherapy.
  • Locally advanced cervical cancer (LACC) presents a complex tumor microenvironment influenced by immune cells.

Purpose of the Study:

  • To evaluate the correlation between tumor loco-regional extension and tumor-infiltrating lymphocyte (TIL) infiltration in LACC before chemoradiotherapy.
  • To assess the association between TILs and PET/CT metabolic metrics in LACC.

Main Methods:

  • Retrospective analysis of 86 LACC patients undergoing PET/CT.
  • Assessment of tumor maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG).
  • Pathological evaluation of intraepithelial TILs (<1% vs >1%) and stromal TILs (<60% vs >60%).

Main Results:

  • No significant association was found between intraepithelial TILs and PET/CT metabolic metrics (SUVmax, MTV).
  • Tumors with <1% intraepithelial TILs showed larger MRI tumor size (p=0.04).
  • High stromal TILs (≥60%) were significantly associated with pelvic lymph node uptake (p=0.009).

Conclusions:

  • Poor or absent intraepithelial TILs correlate with more advanced disease and larger tumor size in LACC.
  • TILs are not associated with tumor metabolic activity as measured by PET/CT.
  • Intraepithelial and stromal TILs should be assessed separately; further research is needed to link metabolic profiles with immune populations for immunotherapy selection.