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Time-dependent in vitro variations of platelet count in samples from subjects with EDTA-induced

Claudia Ghali1, Mariangela Scavone1, Bianca Clerici2

  • 1Laboratorio di Emostasi e Trombosi - Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milano, Italy.

British Journal of Haematology
|March 12, 2024
PubMed
Abstract

No abstract available in PubMed .

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Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...