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Using mycobacterium cell wall fraction to decrease equine chorionic gonadotropin after abortion.

Carleigh E Fedorka1,2, Maria R Schnobrich3, Natacha D Muderspach4

  • 1Department of Veterinary Sciences, University of Kentucky, Lexington, Kentucky, USA.

Equine Veterinary Journal
|March 12, 2024
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Summary
This summary is machine-generated.

Mycobacterium cell wall fraction (MCWF) treatment accelerated equine chorionic gonadotropin (eCG) decline after abortion. This allowed mares to develop pre-ovulatory follicles, enabling repeat breeding attempts within a single season.

Keywords:
endometrial cupsequine abortionequine chorionic gonadotropinhorseimmunomodulation

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Area of Science:

  • Reproductive endocrinology in mares.
  • Immunomodulation and its effects on pregnancy.
  • Veterinary obstetrics and gynecology.

Background:

  • Equine embryonic loss and subsequent endometrial cup development delay return to cyclicity due to equine chorionic gonadotropin (eCG).
  • Current methods to reduce eCG production are largely unsuccessful.
  • Mycobacterium cell wall fraction (MCWF) has been observed to increase pro-inflammatory cytokines.

Purpose of the Study:

  • To assess the efficacy of hysteroscopic-guided MCWF injection for accelerating eCG decline.
  • To evaluate the impact of MCWF on reproductive cyclicity post-abortion.

Main Methods:

  • Mares underwent pharmacological abortion at 40-45 days of gestation.
  • Groups received either MCWF or a control solution via hysteroscopic injection into endometrial cups.
  • Ovarian activity, eCG, and cytokine concentrations were monitored via ultrasonography and serum analysis.

Main Results:

  • MCWF treatment significantly reduced eCG levels within 14 days post-treatment.
  • Increased concentrations of IFN-γ and IL-1β were observed in MCWF-treated mares.
  • 80% of MCWF-treated mares developed pre-ovulatory follicles, compared to 33% in controls.

Conclusions:

  • This study presents the first treatment for accelerated eCG reduction post-abortion in mares.
  • MCWF treatment promotes the development of pre-ovulatory follicles within a month.
  • This facilitates repeat breeding opportunities within the same breeding season.