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Association between stress and catecholamines with painful TMD in children

Claudia Restrepo-Serna1, Adriana Santamaría-Villegas1

  • 1CES-LPH Research Group, Universidad CES, Medellín, Colombia.

International Journal of Paediatric Dentistry
|March 13, 2024
PubMed

Insights

Stress and its biological markers, including dopamine, epinephrine, and norepinephrine, are linked to temporomandibular disorders (TMD) pain in children. This highlights potential new avenues for understanding and managing pediatric TMD.

Area of Science:

  • Pediatric Dentistry
  • Biomarkers
  • Neuroscience

Background:

  • Temporomandibular disorders (TMD) are prevalent in children, often manifesting as myofascial pain and headaches.
  • Biomarkers such as catecholamines (dopamine, epinephrine, norepinephrine) may be influenced by lifestyle factors like screen time and sleep loss, potentially predicting TMD pain.
  • Understanding these associations can open new research avenues for pediatric TMD.

Purpose of the Study:

  • To investigate the relationship between stress, catecholamines, and TMD-related myofascial pain and headaches in children.
  • To identify if stress and specific biomarkers predict pain symptoms in pediatric TMD.

Main Methods:

  • A study involving 66 children aged 9-11 diagnosed with TMD according to the Diagnostic Criteria for TMD (DC/TMD) Axis I.
  • Assessment of perceived stress using the Perceived Stress Scale-Children (PSS-C).
  • Analysis of 24-hour urine samples for catecholamine levels (dopamine, epinephrine, norepinephrine) via liquid chromatography, followed by regression analyses.

Main Results:

  • Perceived stress, dopamine, epinephrine, and norepinephrine were identified as significant predictors of myofascial pain and headache attributed to TMD.
  • Both single and multiple variable logistic regression analyses confirmed these associations.
  • The study included children with a mean age of 10.3 years and a mean stress score of 29 ± 4.

Conclusions:

  • Elevated stress levels and associated biological biomarkers increase the likelihood of developing myofascial pain and headaches in children with TMD.
  • These findings underscore the importance of considering psychological stress and physiological markers in the context of pediatric TMD.
  • Further research into stress management and biomarker monitoring may offer novel therapeutic strategies for children with TMD.
Abstract

Keywords:
childrendopamineepinephrinenorepinephrinestresstemporomandibular disorders

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