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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

Towards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA.

Gavrielle R Untracht^1,2, Madeleine S Durkee³, Mei Zhao⁴

¹Department of Health Technology, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.

Scientific Reports

|March 13, 2024

Summary

A new open-source tool, OCTAVA, provides reliable retinal microvascular analysis from various optical coherence tomography angiography (OCTA) instruments. This enhances the reproducibility of quantitative imaging for disease biomarker discovery.

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Published on: January 12, 2022

Area of Science:

Ophthalmology
Medical Imaging
Biomedical Engineering

Background:

Quantitative assessment of retinal microvasculature in optical coherence tomography angiography (OCTA) is crucial for disease diagnosis and monitoring.
Current OCTA analysis tools lack universality and transparency, leading to inconsistent microvascular metrics across different instruments and datasets.

Purpose of the Study:

To introduce a retinal extension to the OCTA Vascular Analyser (OCTAVA) for robust, user-friendly, and transparent analysis of retinal OCTA images.
To address the need for standardized and reproducible quantitative analysis of retinal microvasculature.

Main Methods:

Development of OCTAVA, an open-source toolbox for analyzing retinal OCTA images from various instruments.
Validation of OCTAVA using datasets from four commercial OCTA instruments across different sites and study cohorts.
Calculation of seven microvascular metrics and six foveal avascular zone metrics.

Main Results:

OCTAVA demonstrated robust performance across diverse OCTA datasets, showing consistent results regardless of the instrument or acquisition site.
The toolbox provided retinal microvascular metric values comparable to existing literature.
OCTAVA reduced the variation in metric values between studies compared to commercial analysis tools.

Conclusions:

OCTAVA offers a standardized, transparent, and user-friendly solution for quantitative analysis of retinal OCTA images.
The public availability of OCTAVA aims to improve research reproducibility and facilitate the identification of reliable biomarkers for ocular and systemic diseases.