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A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

A Morphometric and Cellular Analysis Method for the Murine Mandibular Condyle

Published on: January 11, 2018

BMP2 rs1005464 is associated with mandibular condyle size variation.

Guido Artemio Marañón-Vásquez¹, Mônica Tirre de Souza Araújo¹, Antônio Carlos de Oliveira Ruellas¹

¹Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rua. Prof. Rodolpho Paulo Rocco, 325 - Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-617, Brazil.

Scientific Reports

|March 13, 2024

Summary

This summary is machine-generated.

Single nucleotide polymorphisms (SNPs) in the BMP2 gene, specifically rs1005464, are linked to variations in mandibular condyle size. This finding suggests a potential genetic influence on condyle dimensions.

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Area of Science:

Genetics
Anthropology
Biomedical Engineering

Background:

Mandibular condyle morphology is crucial for jaw function and facial aesthetics.
Genetic factors are known to influence skeletal development, but their specific role in condyle variation requires further investigation.

Purpose of the Study:

To investigate the association between single nucleotide polymorphisms (SNPs) in genes related to endochondral development and quantitative traits of the mandibular condyle.
To determine if specific SNPs influence mandibular condyle shape, size, volume, or symmetry.

Main Methods:

Cone-beam Computed Tomography (CBCT) and genomic DNA were analyzed from 118 individuals.
Morphometric analyses, including Procrustes fit and principal component analysis, were performed on 3D landmarks of the mandibular condyles.
Seven SNPs in BMP2, BMP4, RUNX2, and SMAD6 genes were genotyped, and their association with condylar traits was evaluated using linear models.

Main Results:

A significant association was found between the BMP2 rs1005464 SNP and mandibular condyle centroid size.
Individuals with at least one A allele for BMP2 rs1005464 exhibited larger condylar size compared to GG homozygotes.
The BMP2 rs1005464 SNP, along with age and sex, explained 17% of the variation in condylar size. No significant associations were found for shape, volume, or symmetry.

Conclusions:

The BMP2 rs1005464 SNP may be associated with variations in mandibular condyle size.
This study highlights a potential genetic marker influencing condyle dimensions, contributing to our understanding of craniofacial development.