Related Experiment Video
Updated: Jul 1, 2025

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
Published on: April 19, 2024
Pressure Support Ventilation Versus T-piece as Spontaneous Breathing Trials for Extubation of Patients with Chronic
Luiza Mendes Fonseca1, Pedro Matos da Câmara2, Iane Miguel Pereira Lettieri3
1Department of Medicine, Faculty of Medical Sciences of Minas Gerais, Inconfidentes Street, Number 443, apartment, Belo Horizonte, Minas Gerais, 1102, Brazil. luizamf1998@gmail.com.
Background:
Weaning patients with COPD from mechanical ventilation (MV) presents a challenge, as literature on this topic is limited. This study compares PSV and T-piece during spontaneous breathing trials (SBT) in this specific population.
Methods:
A search of PubMed, EMBASE, and Cochrane in September 2023 yielded four randomized controlled trials (RCTs) encompassing 560 patients. Among these, 287 (51%) used T-piece during SBTs.
Results:
The PSV group demonstrated a significant improvement in the successful extubation rate compared to the T-piece (risk ratio [RR] 1.14; 95% confidence interval [CI] 1.03-1.26; p = 0.02). Otherwise, there was no statistically significant difference in the reintubation (RR 1.07; 95% CI 0.79-1.45; p = 0.67) or the ICU mortality rates (RR 0.99; 95% CI 0.63-1.55; p = 0.95).
Conclusion:
Although PSV in SBTs exhibits superior extubation success, consistent weaning protocols warrant further exploration through additional studies.
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