A pan-cancer analysis of the oncogenic and immunological roles of transglutaminase 1 (TGM1) in human cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Transglutaminase type 1 (TGM1) shows varied expression in tumors and impacts survival in several cancers. TGM1 also correlates with tumor stemness and immune cell infiltration, suggesting its potential as a prognostic marker and drug target.
Area Of Science
- Oncology
- Molecular Biology
- Immunology
Background
- Limited research exists on transglutaminase type 1 (TGM1) in tumor biology.
- Understanding TGM1's role in cancer is crucial for developing new therapeutic strategies.
Purpose Of The Study
- To comprehensively analyze TGM1 expression across diverse cancer types.
- To determine the prognostic significance of TGM1 in tumors.
- To investigate the association between TGM1 and the tumor immune microenvironment.
Main Methods
- Utilized pan-cancer and mutational data from The Cancer Genome Atlas (TCGA) database.
- Analyzed TGM1 expression, prognosis, tumor heterogeneity, stemness, mutation landscape, and RNA modification.
- Investigated TGM1's relationship with tumor immunity using the TIMER method.
Main Results
- TGM1 exhibits differential expression in various tumors and normal tissues, correlating with survival outcomes in KIRC, ACC, SKCM, LIHC, and STES.
- Found a negative correlation between TGM1 expression and tumor stemness indicators in LIHC.
- Observed significant associations between TGM1 expression and immune cell infiltration (CD4+ T cells, CD8+ T cells, neutrophils, dendritic cells) in BLCA and BRCA.
Conclusions
- Transglutaminase type 1 (TGM1) demonstrates potential as a prognostic biomarker in several cancer types.
- TGM1 may represent a viable therapeutic target for cancer treatment.
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