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Subtyping of Campylobacter jejuni ssp. doylei Isolates Using Mass Spectrometry-based PhyloProteomics MSPP
Published on: October 30, 2016
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Human Campylobacter spp. infections in Italy
Verena Zerbato1, Stefano Di Bella2, Riccardo Pol3
1Infectious Diseases Unit, Trieste University Hospital (ASUGI), Trieste, Italy. verena.zerbato@gmail.com.
Summary
Campylobacter infections in Italy show decreasing resistance to fluoroquinolones and tetracyclines. However, macrolides remain effective against these common enteric pathogens.
Area of Science:
- Microbiology
- Infectious Diseases
- Epidemiology
Background:
- Campylobacter species are a leading cause of bacterial gastroenteritis globally.
- Antimicrobial resistance in Campylobacter poses a significant public health challenge.
- Recent epidemiological data on Campylobacter infections in Italy were limited to 2013-2016.
Purpose of the Study:
- To analyze national epidemiological and microbiological data for human Campylobacter infections in Italy.
- To track trends in antimicrobial resistance patterns for Campylobacter species from 2017-2021.
Main Methods:
- Data collected from 19 hospitals across 13 Italian regions.
- Bacterial identification using mass spectrometry.
- Antimicrobial susceptibility testing via Etest or Kirby-Bauer methods (EUCAST criteria).
Main Results:
- Over 5400 Campylobacter isolates identified, predominantly C. jejuni (83.7%) and C. coli (13.5%).
- High resistance rates observed for ciprofloxacin (75.5%) and tetracyclines (54.8%).
- Resistance to macrolides (erythromycin, clarithromycin, azithromycin) remained low (<5%), and significantly decreased for ciprofloxacin and tetracyclines over the study period.
Conclusions:
- Campylobacter resistance to fluoroquinolones and tetracyclines in Italy is declining but remains high.
- Macrolide antibiotics maintain good efficacy against Campylobacter infections in Italy.
- Continued surveillance is crucial for monitoring antimicrobial resistance trends.
Keywords:
Campylobacter jejuni(6): Campylobacter sppAntimicrobial resistanceItalyMultidrug-resistantSurveillanceMore Related Videos
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