In vitro activity of cefbuperazone against anaerobic bacteria

The in vitro activity of cefbuperazone was compared with that of cefoxitin, moxalactam, and piperacillin against 305 strains of anaerobic bacteria. Piperacillin was the most active overall, inhibiting 97% of all anaerobes tested at 128 micrograms/ml. Cefbuperazone had poor activity against the Bacteroides fragilis group and Clostridium difficile (43 and 0% susceptible, respectively) but good activity (90.5%) against all other anaerobic bacterial species tested.