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Unraveling Chronic Cardiovascular and Kidney Disorder through the Butterfly Effect
Dimitri Bedo1,2, Thomas Beaudrey1,3, Nans Florens1,3
1Nephrology Department, Hopitaux Universitaires de Strasbourg, F-67091 Strasbourg, France.
Diagnostics (Basel, Switzerland)
|March 13, 2024
Summary
The "butterfly effect" in Chronic Cardiovascular and Kidney Disorder (CCKD) shows how acute kidney injury and heart failure worsen each other. New therapies and targets offer hope for managing this complex, intertwined condition.
Area of Science:
- Cardiology
- Nephrology
- Translational Medicine
Background:
- Chronic Cardiovascular and Kidney Disorder (CCKD) is a growing healthcare concern.
- CCKD involves complex interactions between cardiac and renal systems.
- The 'butterfly effect' describes how acute organ injury in one system progressively impairs the other.
Purpose of the Study:
- To explore the pathophysiology of the 'butterfly effect' in CCKD.
- To review current and emerging therapies for CCKD.
- To identify novel therapeutic targets for CCKD.
Main Methods:
- Literature review of CCKD pathophysiology.
- Analysis of the interplay between acute kidney injury (AKI) and heart failure (HF).
- Evaluation of emerging therapeutic agents and novel targets.
Main Results:
- AKI and HF significantly exacerbate each other in CCKD.
- Renin-angiotensin-aldosterone system (RAAS) inhibitors, SGLT2 inhibitors, and GLP1 agonists show therapeutic promise.
- Galectin-3 inhibition and IL33/ST2 pathway modulation are potential novel therapeutic avenues.
Conclusions:
- Recognizing the interconnectedness of cardiac and renal dysfunction is crucial for CCKD management.
- Emerging therapies and targets offer new strategies to alter the course of CCKD.
- Integrated treatment approaches are needed for this multifaceted syndrome.
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