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Lower Rates of Hypocalcemia Following Near-Infrared Autofluorescence Use in Thyroidectomy: A Meta-Analysis of RCTs
Karthik N Rao1,2, Renu Rajguru3, Prajwal Dange1
1Department of Head and Neck Oncology, All India Institute of Medical Sciences, Raipur 492099, India.
Diagnostics (Basel, Switzerland)
|March 13, 2024
Summary
Near-infrared autofluorescence (NIRAF) significantly reduces hypocalcemia after total thyroidectomy. This technique aids in preserving parathyroid gland function, lowering complication rates in surgical patients.
Area of Science:
- Endocrinology
- Surgical Oncology
- Medical Technology
Background:
- Iatrogenic injury to parathyroid glands is a common complication after total thyroidectomy.
- Postoperative hypocalcemia is a frequent concern following this procedure.
Purpose of the Study:
- To evaluate the efficacy of near-infrared autofluorescence (NIRAF) in minimizing hypocalcemia after total thyroidectomy.
- Assessing NIRAF's role in preventing parathyroid gland-related complications.
Main Methods:
- A systematic review and meta-analysis of randomized controlled trials.
- Searched PubMed, Scopus, and Google Scholar for relevant studies.
- Included trials reporting hypocalcemia outcomes after total thyroidectomy using NIRAF.
Main Results:
- Analysis of 9 randomized trials involving 1363 patients (636 NIRAF, 637 non-NIRAF).
- NIRAF significantly reduced overall and temporary hypocalcemia rates.
- A trend towards lower permanent hypocalcemia in the NIRAF group, though not statistically significant.
Conclusions:
- Near-infrared autofluorescence is effective in reducing postoperative hypocalcemia after total thyroidectomy.
- NIRAF assists in preserving parathyroid gland function during surgery.
- Level of evidence: 1.
