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Related Concept Videos

Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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Related Experiment Video

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Doppler Optical Coherence Tomography of Retinal Circulation
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Clinical Evaluation of a New Spectral-Domain Optical Coherence Tomography-Based Biometer.

Jorge L Alió1,2, Marina José-Martínez1, Antonio Martínez-Abad1

  • 1Research and Development Department, Vissum Grupo Miranza, 03016 Alicante, Spain.

Diagnostics (Basel, Switzerland)
|March 13, 2024
PubMed
Summary

The new VEMoS-AXL optical biometer shows good repeatability for eye measurements. It largely agrees with the gold standard swept-source OCT biometer, except for anterior chamber depth.

Keywords:
anterior chamber depthaxial lengthcentral corneal thicknessoptical biometryspectral-domain optical coherence tomographyswept-source optical coherence tomography

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Area of Science:

  • Ophthalmology
  • Biomedical Optics
  • Medical Devices

Background:

  • Optical biometry is crucial for accurate refractive error assessment.
  • Spectral domain optical coherence tomography (SD-OCT) offers high-resolution imaging for ocular measurements.
  • Swept-source optical coherence tomography (SS-OCT) is considered a gold standard for biometry.

Purpose of the Study:

  • To evaluate the intrasession repeatability of the VEMoS-AXL SD-OCT biometer.
  • To compare the VEMoS-AXL system's measurements with a gold standard SS-OCT biometer.
  • To assess the agreement and clinical relevance of measurements between the two devices.

Main Methods:

  • Biometric analysis of 120 healthy eyes using the VEMoS-AXL SD-OCT system (three consecutive measurements).
  • Subsequent single measurement using a SS-OCT biometer for comparison.
  • Agreement analysis including limits of agreement (LoA) for axial length (AL), central corneal thickness (CCT), and anterior chamber depth (ACD).

Main Results:

  • The VEMoS-AXL system demonstrated high intrasession repeatability with low standard deviations for AL (0.004 mm), CCT (4.394 µm), and ACD (0.017 mm).
  • Good agreement was found between VEMoS-AXL and SS-OCT for AL (LoA: -0.04 to 0.03 mm) and CCT (LoA: -4.36 to 14.38 µm).
  • Clinically relevant differences were observed for ACD measurements (LoA: 0.03 to 0.21 mm).

Conclusions:

  • The VEMoS-AXL system provides consistent and repeatable ocular biometric measurements.
  • Most VEMoS-AXL measurements, particularly AL and CCT, are interchangeable with the SS-OCT gold standard.
  • Further investigation may be needed for ACD measurements due to observed clinical relevance differences.