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Current Status of Targeted Therapy for Biliary Tract Cancer in the Era of Precision Medicine

Takafumi Mie1, Takashi Sasaki1, Takeshi Okamoto1

  • 1Department of Hepato-Biliary-Pancreatic Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.

Cancers
|March 13, 2024
PubMed

Insights

Precision medicine offers new hope for advanced biliary tract cancer (BTC) patients. Genomic analysis reveals targetable alterations, guiding second-line treatment options and clinical trials for improved outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Precision Medicine

Background:

  • Advanced biliary tract cancer (BTC) has limited second-line treatment options after initial chemotherapy.
  • Comprehensive genomic analysis is revealing actionable targets in BTC.

Purpose of the Study:

  • To review current precision medicine strategies for advanced BTC.
  • To summarize available clinical trials for patients with advanced BTC.

Main Methods:

  • Review of scientific literature and clinical trial databases.
  • Analysis of genomic alterations in advanced BTC.

Main Results:

  • Nearly half of advanced BTC patients possess targetable genetic alterations.
  • Identified targets include FGFR, IDH, BRAF, HER2, MSI-high, NTRK, RET, and PARP.

Conclusions:

  • Precision medicine offers promising therapeutic avenues for advanced BTC.
  • Targeted therapies and clinical trials are expanding treatment possibilities for BTC patients.
Keywords:
biliary tract cancercholangiocarcinomaprecision medicinetargeted therapy

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