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Related Experiment Video

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Six-Month Prostate Cancer Empowerment Program (PC-PEP) Improves Urinary Function: A Randomized Trial.

Tarek Lawen1, Gabriela Ilie1,2,3, Ross Mason1

  • 1Department of Urology, Dalhousie University, Halifax, NS B3H 4R2, Canada.

Cancers
|March 13, 2024
PubMed
Summary

The Prostate Cancer-Patient Empowerment Program (PC-PEP) significantly improved urinary function in men undergoing curative prostate cancer treatment. This home-based program offers a viable clinical integration for managing lower urinary tract symptoms.

Keywords:
behavioural interventioncancer survivorshipeHealtherectile dysfunctionincontinencepatient education and activationpelvic floor muscle training (PFMT)prostate cancersexual functionurinary function

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Area of Science:

  • Oncology
  • Urology
  • Health Psychology

Background:

  • Curative treatments for prostate cancer (PC) often lead to significant urinary, bowel, sexual, and hormonal dysfunctions.
  • Patient-reported outcomes are crucial for evaluating the effectiveness of interventions in managing these side effects.
  • A home-based empowerment program may offer a scalable solution for improving quality of life post-treatment.

Purpose of the Study:

  • To evaluate the impact of a six-month home-based Prostate Cancer-Patient Empowerment Program (PC-PEP) on patient-reported outcomes.
  • To assess the program's effects on urinary, bowel, sexual, and hormonal function in men with curative prostate cancer (PC) compared to standard care.
  • To determine the long-term benefits of PC-PEP at 12 months post-intervention.

Main Methods:

  • A secondary analysis of a crossover clinical trial involving 128 men with PC undergoing surgery or radiotherapy.
  • Randomization to either the PC-PEP intervention group or a waitlist-control group, followed by a crossover.
  • PC-PEP included daily emails, video-guided exercises (aerobic, strength, PFMT), dietary guidance, stress management, and social support.
  • International Prostate Symptom Score (IPSS) and Expanded Prostate Cancer Index Composite (EPIC) questionnaires were used for assessments at baseline, 6, and 12 months.

Main Results:

  • At 6 months, PC-PEP participants reported significantly improved urinary bother (IPSS, p = 0.004) and continence (EPIC, p < 0.001) compared to controls.
  • Sustained improvements in urinary continence were observed at 12 months (p = 0.002).
  • Surgery patients in the control group had higher odds of moderate to severe urinary problems at 6 and 12 months compared to PC-PEP participants.

Conclusions:

  • The Prostate Cancer-Patient Empowerment Program (PC-PEP) effectively improves lower urinary tract symptoms in men with curative prostate cancer.
  • PC-PEP demonstrates suitability for clinical integration to manage urinary dysfunction post-treatment.
  • The program's benefits extend beyond physical symptoms, potentially including established mental health advantages.