Related Experiment Video

Updated: Jul 1, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

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Special Issue of Pathogenesis of Pregnancy-Related Complications, 2023

Ilona Hromadnikova1

  • 1Department of Molecular Biology and Cell Pathology, Third Faculty of Medicine, Charles University, 100 00 Prague, Czech Republic.

International Journal of Molecular Sciences
|March 13, 2024
PubMed

Insights

This Special Issue covers critical pregnancy complications including preeclampsia, HELLP syndrome, gestational diabetes, and fetal growth issues. It also addresses pregnancy-related psychosis and kidney injury, highlighting key areas for research and clinical attention.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Reproductive Health

Background:

  • This Special Issue addresses significant pregnancy complications such as preeclampsia (PE), haemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome.
  • It also covers gestational diabetes mellitus (GDM), foetal growth restriction (FGR), and small-for-gestational-age (SGA) foetuses.
  • Additional topics include miscarriage, stillbirth, first-episode psychosis (FEP) during pregnancy, and pregnancy-related acute kidney injury (PR-AKI).

Discussion:

  • The collection focuses on conditions impacting maternal and fetal well-being during gestation.
  • It highlights the multifaceted nature of pregnancy complications and their management.
  • Understanding these conditions is crucial for improving obstetric outcomes.

Key Insights:

  • Preeclampsia and HELLP syndrome represent severe hypertensive disorders of pregnancy.
  • Gestational diabetes and fetal growth abnormalities require careful monitoring and intervention.
  • Pregnancy-specific mental health issues like FEP and PR-AKI present unique clinical challenges.

Outlook:

  • Further research is needed to elucidate the pathophysiology and improve treatment strategies for these complex conditions.
  • Enhanced diagnostic tools and personalized management approaches are essential for better maternal and infant outcomes.
  • This Special Issue serves as a vital resource for clinicians and researchers in maternal-fetal medicine.

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