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Rapid Model to Evaluate the Anti-Obesity Potential of a Combination of Syzygium aromaticum Clove and Cuminun cyminum Cumin on C57BL6/j Mice Fed High-Fat Diet
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Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment

Gladys Maribel Hidalgo-Lozada1, Angelica Villarruel-López2, Karla Nuño3

  • 1Institute of Science and Technology for Health Innovation, Guadalajara 44770, Mexico.

International Journal of Molecular Sciences
|March 13, 2024
PubMed

Insights

Natural bioactive compounds offer promising alternatives for obesity management. These compounds, found in supplements and foods, show potential for treating obesity and related conditions with fewer side effects than traditional therapies.

Area of Science:

  • Nutritional Science
  • Pharmacology
  • Biochemistry

Background:

  • Global rise in obesity and associated comorbidities presents a significant health challenge.
  • Existing obesity therapies often have adverse effects, high costs, and limited accessibility.
  • Natural bioactive compounds are emerging as viable therapeutic alternatives.

Purpose of the Study:

  • To provide a comprehensive review of nature-based therapeutic options for obesity.
  • To explore the molecular mechanisms and clinical evidence of various bioactive compounds.
  • To offer insights for future research and clinical application in obesity management.

Main Methods:

  • Systematic literature review of clinical studies and molecular research on bioactive compounds.
  • Analysis of signaling pathways and gene expression related to obesity.
  • Evaluation of evidence for compounds such as epigallocatechin-3-gallate, resveratrol, and curcumin.

Main Results:

  • Bioactive compounds interact with endocrine, nervous, and gastroenteric systems.
  • Mechanisms include regulating starvation-satiety, activating brown adipose tissue, and improving insulin sensitivity.
  • Compounds like epigallocatechin-3-gallate, ellagic acid, resveratrol, and berberine show significant therapeutic potential.

Conclusions:

  • Nature-based compounds offer a promising, potentially safer, and more accessible approach to obesity treatment.
  • Further research into molecular, genetic, and physiological bases is warranted.
  • These findings support the integration of bioactive compounds into future clinical practice for obesity.
Keywords:
berberinecardiovascular risk factorscarotenoidsellagic acidfunctional foodsnatural compoundsobesityprobioticsresveratroltreatment

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