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Exploring the Interplay between Bone Marrow Stem Cells and Obesity.

Fiorenzo Moscatelli¹, Antonietta Monda², Giovanni Messina²

¹Department of Wellbeing, Nutrition and Sport, Pegaso Telematic University, 80143 Naples, Italy.

International Journal of Molecular Sciences

|March 13, 2024

Summary

Obesity involves excessive fat accumulation and inflammation. Bone marrow stem cells influence fat formation and metabolic balance, highlighting a complex interplay in this chronic disease.

Keywords:

adipose tissue bone marrow inflammation mesenchymal stem cells obesity stem cells

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Area of Science:

Biomedical Science
Stem Cell Biology
Metabolic Disorders

Background:

Obesity is a complex, chronic, inflammatory disease characterized by excessive adipose tissue accumulation.
Adipose tissue is a diverse organ influenced by individual characteristics and location.
Emerging research explores the link between bone marrow stem cells and obesity.

Purpose of the Study:

To review current research on the relationship between bone marrow stem cells and obesity.
To elucidate the role of bone marrow in adipogenesis and inflammation within the context of obesity.

Main Methods:

Narrative review of existing scientific literature.
Analysis of studies investigating bone marrow stem cell differentiation and the bone marrow microenvironment in obesity.

Main Results:

Mesenchymal stem cells in bone marrow are crucial for adipogenesis (fat cell formation).
Obesity may alter the bone marrow microenvironment, affecting stem cell differentiation and fat storage.
Bone marrow's immune functions add complexity to its role in obesity.

Conclusions:

Bone marrow stem cells play a significant role in adipogenesis and metabolic balance.
The bone marrow microenvironment is a key factor in obesity development and progression.
Further research is needed to fully understand the multifaceted connection between bone marrow and obesity.