Related Experiment Video
Updated: Jul 1, 2025

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
Published on: April 11, 2025
The Killer's Web: Interconnection between Inflammation, Epigenetics and Nutrition in Cancer
Marisabel Mecca1, Simona Picerno1, Salvatore Cortellino2,3,4
1Laboratory of Preclinical and Translational Research, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), 85028 Rionero in Vulture, PZ, Italy.
Abstract:
Inflammation is a key contributor to both the initiation and progression of tumors, and it can be triggered by genetic instability within tumors, as well as by lifestyle and dietary factors. The inflammatory response plays a critical role in the genetic and epigenetic reprogramming of tumor cells, as well as in the cells that comprise the tumor microenvironment. Cells in the microenvironment acquire a phenotype that promotes immune evasion, progression, and metastasis. We will review the mechanisms and pathways involved in the interaction between tumors, inflammation, and nutrition, the limitations of current therapies, and discuss potential future therapeutic approaches.
Related Concept Videos
Epigenetic Regulation
X-chromosome...
Psychoneuroimmunology: Diabetes and Cancer
The Tumor Microenvironment
Cancer Prevention
Some...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

