A Blended Vitamin Supplement Improves Spatial Cognitive and Short-Term Memory in Aged Mice

Area of Science:

• Gerontology
• Nutritional Science
• Neuroscience

Background:

• Antioxidant supplements can be beneficial, but optimal combinations and dosages are unclear for consumers.
• Aging is associated with cognitive decline and reduced physical capacity.

Purpose of the Study:

• To investigate the effects of a blended antioxidant supplement on cognitive function and physical performance in aging mice.
• To provide evidence-based information for consumers regarding antioxidant supplementation.

Main Methods:

• 18-month-old C57BL/6 mice received a blended supplement for one month.
• Cognitive function was assessed using the Morris water maze and Y-maze.
• Physical endurance was evaluated through treadmill tests.
• Serum biochemistry was analyzed post-mortem.

Main Results:

• Supplement-treated mice showed significant improvements in spatial cognition and short-term memory (spontaneous alternative ratio increased from 49.5% to 68.67%, p < 0.01).
• Treadmill test results indicated a significant increase in running distance after supplementation (111.4% vs. 91.17% increase, p < 0.04).
• Serum analysis revealed decreased aspartate aminotransferase, alanine aminotransferase, and total cholesterol levels.

Conclusions:

• Continuous intake of a blended supplement may enhance cognitive function in aging individuals.
• Supplementation may help suppress age-related muscle decline and improve physical endurance.
• No significant changes in neurotrophic factors like nerve growth factor (NGF) or brain-derived neurotrophic factor (BDNF) were observed.