The Role of Circular RNA for Early Diagnosis and Improved Management of Patients with Cardiovascular Diseases

Area of Science:

• Molecular Biology
• Genetics
• Cardiology

Background:

• Cardiovascular diseases (CVDs) cause nearly 18 million deaths annually.
• Circular RNAs (circRNAs) are increasingly recognized for their regulatory roles in biological processes.
• Their specific involvement in CVD pathogenesis requires further elucidation.

Purpose of the Study:

• To provide a comprehensive overview of circRNA properties, expression, classification, and functions.
• To explore the implications of circRNAs in various cardiovascular diseases.
• To highlight the potential of circRNAs in the early diagnosis and treatment of CVDs.

Main Methods:

• Literature review and synthesis of existing research on circRNAs.
• Analysis of circRNA regulatory mechanisms (gene expression, protein/miRNA interactions, translation).
• Examination of circRNA roles in specific cardiovascular conditions.

Main Results:

• CircRNAs function as regulatory molecules, influencing gene expression and cellular processes.
• They are involved in cell division, proliferation, growth, and development.
• Specific circRNAs have been implicated in heart failure, hypertension, ischemia/reperfusion injury, myocardial infarction, cardiomyopathies, atherosclerosis, and arrhythmia.

Conclusions:

• CircRNAs possess diverse properties and functions relevant to cardiovascular health.
• Their dysregulation is linked to the development and progression of multiple CVDs.
• CircRNAs represent promising biomarkers for CVD diagnosis and potential therapeutic targets.