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Updated: Jul 1, 2025

Expression, Solubilization, and Purification of Eukaryotic Borate Transporters
Published on: March 7, 2019
An Exceptionally Active and Highly Selective Perchlorate Transporter Containing a Trimesic Amide Scaffold
Shaowen Deng1, Zhongyan Li2, Lin Yuan1
1College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425100, China.
Abstract:
We report here a series of alkyl group-modified trimesic amide molecules (TAs) with excellent anion transport activities. Among them, TA6, with the highest ion transport activity and excellent selectivity, efficiently transports anions across the membrane in the order of ClO4- > I- > NO3- > Br- > Cl-, with an EC50 value as low as 17.6 nM (0.022 mol% relative to lipid molecules) for ClO4-, which outperforms other anions by 5- to 22-folds and manifests as the best perchlorate transporter ever reported.
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