Related Experiment Video

Updated: Jul 7, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.7K

High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants (HIDVID Trial): Study Protocol for a

Dominika Paw1, Renata Bokiniec1, Alicja Kołodziejczyk-Nowotarska1

  • 1Department of Neonatology and Neonatal Intensive Care, Medical University of Warsaw, 00-315 Warsaw, Poland.

Nutrients
|March 13, 2024
PubMed

Insights

This study investigated monitored vitamin D supplementation for preterm infants. Higher initial doses may reduce neonatal sepsis and bone disease, improving infant health outcomes.

Area of Science:

  • Neonatology
  • Pediatric Endocrinology
  • Nutritional Science

Background:

  • Vitamin D deficiency is linked to bone disease and immune issues in preterm infants.
  • Preterm infants (24-32 weeks gestation) are at high risk for these complications.
  • Early assessment of vitamin D status is crucial for intervention.

Purpose of the Study:

  • To evaluate the efficacy of monitored vitamin D supplementation in preterm infants.
  • To determine if a high initial dose of vitamin D reduces neonatal sepsis and metabolic bone disease.
  • To compare monitored supplementation with standard dosing protocols.

Main Methods:

  • Randomized controlled trial involving preterm infants (24-32 weeks gestation).
  • Measurement of 25-hydroxyvitamin D, parathyroid hormone, and interleukin-6 levels.
  • Supplementation groups: monitored (1000 IU/day initially) vs. controlled (250-500 IU/day).
  • Monitoring continued to 35 weeks postconceptional age.

Main Results:

  • Primary endpoint: percentage of infants with deficient/suboptimal 25-hydroxyvitamin D at 28 days.
  • Secondary endpoints: incidence of sepsis, osteopenia, hyperparathyroidism, and IL-6 levels.
  • Analysis of vitamin D levels at 35 weeks postconceptional age.

Conclusions:

  • Monitored vitamin D supplementation may be more effective in achieving optimal levels in preterm infants.
  • High initial vitamin D doses warrant further investigation for preventing neonatal complications.
  • Optimizing vitamin D status is critical for preterm infant development and health.

Keywords:
infantinterleukin-6osteopeniaparathyroid hormoneprematuresepsisvitamin D

More Related Videos

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling07:11

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Published on: February 5, 2019

9.0K
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.1K

Related Concept Videos

Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Bioavailability Study Design: Single Versus Multiple Dose Studies01:11

Bioavailability Study Design: Single Versus Multiple Dose Studies

Bioavailability studies are essential for understanding how a drug is absorbed, distributed, metabolized, and excreted in the body. These studies assess the extent and rate at which the active pharmaceutical agent becomes available at the site of action. The design of bioavailability studies can involve single-dose or multiple-dose regimens, each with distinct advantages and limitations.Single-dose studies are the preferred approach due to their simplicity and reduced drug exposure for...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...