Near-Infrared Fluorescence Imaging Sensor with Laser Diffuser for Visualizing Photoimmunotherapy Effects under...

Area of Science:

• Medical Imaging
• Endoscopy
• Photodynamic Therapy

Background:

• Evaluating drug efficacy of tumor-selective photosensitive substances relies on fluorescence imaging.
• Current gastrointestinal endoscopy methods face challenges in fluorescence observation due to filter integration issues.

Purpose of the Study:

• To develop an innovative endoscopic device for effective fluorescence imaging of tumor-selective photosensitive drugs.
• To overcome limitations of current endoscopic imaging techniques for drug efficacy assessment.

Main Methods:

• A novel device integrating a narrow camera and laser diffuser was developed.
• The device was designed for fluorescence imaging through a standard forceps port.
• The system demonstrated successful delivery of an NIR fluorescence imaging sensor through a 3.2 mm port.

Main Results:

• Fluorescence images of Cetuximab-IR700 were successfully obtained in mice models.
• The fluorescence intensity measurements confirmed a decay within 330 seconds.
• The developed device enabled visualization of fluorescence via a forceps port during simulated endoscopic procedures.

Conclusions:

• The developed endoscopic device facilitates fluorescence imaging through a forceps port, overcoming previous limitations.
• This technology is promising for real-time drug efficacy evaluation and optimizing irradiation doses for photosensitive therapies.
• The device has potential applications in improving tumor-selective photosensitive substance treatments during endoscopy.