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Updated: Jul 1, 2025

Cryosectioning Method for Microdissection of Murine Colonic Mucosa
Published on: July 12, 2015
The evolving understanding of histology as an endpoint in ulcerative colitis
Shintaro Akiyama1, Yusuke Miyatani1, David T Rubin1
1Inflammatory Bowel Disease Center, The University of Chicago Medicine, Chicago, IL, USA.
Abstract:
A therapeutic goal for patients with ulcerative colitis (UC) is deep remission including clinical remission and mucosal healing. Mucosal healing was previously defined by endoscopic appearance, but recent studies demonstrate that histological improvements can minimize the risks of experiencing clinical relapse after achieving endoscopic remission, and there is growing interest in the value and feasibility of histological targets of treatment in inflammatory bowel disease, and specifically UC. In this review article, we identify remaining challenges and discuss an evolving role of histology in the management of UC.
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