Tissue Engineering Scaffolds Loaded With a Variety of Plant Extracts: Novel Model in Breast Cancer Therapy
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Reyhaneh Azhari Rad1, Yasaman Naghdi1, Mobina Majidi Jamalabadi2
1Student Research Committee, School of Paramedicine, Shahroud University of Medical Sciences, Shahroud, Iran.
Abstract:
Despite recent improvements in detecting and managing breast cancer (BC), it continues to be a major worldwide health concern that annually affects millions of people. Exploring the anti-BC potentials of natural compounds has received a lot of scientific attention due to their multi-target mode of action and good safety profiles because of these unmet needs. Drugs made from herbs are secure and have a lot fewer negative effects than those made from synthetic materials. Early stage patients benefit from breast-conserving surgery, but the risk of local recurrence remains, necessitating implanted scaffolds. These scaffolds provide residual cancer cell killing and tailored drug delivery. This review looks at plant extract-infused tissue engineering scaffolds, which provide a novel approach to treating BC. By offering patient individualized, safer treatments, these scaffolds could completely change how BC is treated.
Insights
Natural compounds show promise for breast cancer treatment. Plant extract-infused tissue engineering scaffolds offer a novel, safer approach for personalized breast cancer therapy, potentially reducing recurrence.
Area of Science:
- Oncology
- Biomaterials Science
- Pharmacology
Background:
- Breast cancer (BC) remains a significant global health challenge despite advancements in detection and management.
- Existing treatments have limitations, including the risk of local recurrence after surgery and side effects from synthetic drugs.
- Natural compounds are gaining attention for their multi-target action and favorable safety profiles in cancer research.
Purpose of the Study:
- To review the potential of plant extract-infused tissue engineering scaffolds for breast cancer (BC) treatment.
- To explore the use of these novel scaffolds as a method for delivering anti-cancer agents and managing residual disease.
- To highlight the advantages of natural compounds and tissue engineering in developing safer, personalized BC therapies.
Main Methods:
- Literature review of studies on tissue engineering scaffolds combined with natural compounds for breast cancer treatment.
- Analysis of the mechanisms by which these scaffolds target residual cancer cells and deliver therapeutic agents.
- Evaluation of the safety and efficacy profiles of natural compounds in the context of tissue engineering applications.
Main Results:
- Plant extract-infused tissue engineering scaffolds represent a promising novel approach for breast cancer therapy.
- These scaffolds can facilitate targeted drug delivery and residual cancer cell killing, addressing local recurrence.
- Natural compounds offer a safer alternative to synthetic drugs, with fewer adverse effects.
Conclusions:
- Tissue engineering scaffolds incorporating plant extracts provide a new avenue for personalized and safer breast cancer treatment.
- This innovative approach has the potential to significantly improve outcomes for breast cancer patients, particularly in managing post-surgical recurrence.
- The integration of natural compounds into biomaterials offers a promising strategy to overcome limitations of current breast cancer therapies.
