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Pathogens in FRI - Do bugs matter? - An analysis of FRI studies to assess your enemy

Emmet Thompson1, Amir Qureshi1

  • 1Limb Reconstruction Service, Trauma & Orthopaedic Department, University Hospital Southampton, Southampton, UK.

Journal of Orthopaedics
|March 13, 2024
PubMed

Insights

Fracture-related infections (FRIs) pose significant challenges in orthopaedics, risking limb function loss. This review covers evolving definitions, diagnostics, and treatments for FRIs, including complex pathogens and resistance mechanisms.

Area of Science:

  • Orthopaedic Surgery
  • Infectious Diseases
  • Microbiology

Background:

  • Fracture-related infection (FRI) is a severe complication in orthopaedic surgery, leading to significant patient morbidity and healthcare costs.
  • The complex nature of FRI presents diagnostic and therapeutic challenges for clinicians.
  • Common pathogens include Staphylococcus aureus, polymicrobial infections, and multidrug-resistant organisms (MDROs).

Purpose of the Study:

  • To provide a comprehensive review of fracture-related infections (FRIs).
  • To highlight evolving definitions, diagnostic modalities, and treatment strategies for FRIs.
  • To discuss microbial resistance mechanisms and advancements in combating these infections.

Main Methods:

  • In-depth literature review of recent and seminal research on fracture-related infections.
  • Focus on common pathogens, resistance mechanisms, and treatment advancements.

Main Results:

  • Fracture-related infections (FRIs) are challenging due to unique pathogen characteristics and resistance.
  • Evolving definitions and diagnostic approaches are crucial for effective management.
  • Modern evidence-based medical and surgical strategies are advancing FRI treatment.

Conclusions:

  • Effective management of fracture-related infections (FRIs) requires a thorough understanding of pathogens and resistance.
  • Continuous advancements in medical and surgical interventions are vital for improving patient outcomes.
  • Addressing the complexities of FRIs is essential to prevent limb dysfunction and amputation.
Keywords:
Bacterial resistanceBiofilmDiagnosisFracture-related infectionHealthcare costsMicrobiology

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