Day-of-the-week variation of sudden unexpected cardiac death
Hanna Latola1, Severi M Mattila1, Lasse Pakanen2,3
1Research Unit of Biomedicine and Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland.
Background:
There has been some controversy about the day-of-the-week (septadian) variation of unexpected sudden cardiac death (SCD).
Methods:
We evaluated the incidence of unexpected SCD on different days of the week in a consecutive series of 5869 SCD victims from Northern Finland [the FINGESTURE study (Finnish Genetic Study of Arrhythmic Events)]. As it is mandatory in Finland, a medico-legal autopsy was performed on all unexpected sudden death victims. The autopsies were performed between the years 1998-2017.
Results:
The mean incidence of unexpected SCD was higher at weekends (during the days from Friday to Sunday, peaking on Saturday) than during the days from Monday to Thursday (8.54 ± 0.72 vs. 7.22 ± 0.19 SCDs per day of the week per 100,000 inhabitants per year, p < 0.001). Regardless of sex or ischemic versus non-ischemic etiology of SCD, the distribution of the occurrence of SCD among the days of the week was similar compared with the whole SCD cohort.
Conclusion:
The incidence of unexpected SCD was highest at weekends (during the days from Friday to Sunday, peaking on Saturday).
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