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Updated: Jul 1, 2025
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
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Prognostic significance of a panel of two biomarkers (E-cadherin and CD105) in laryngeal cancer
Elvir Zvrko1,2, Ljiljana Vuckovic2,3, Miodrag Radunovic2,4
1Department of Otorhinolaryngology, Clinical Centre of Montenegro, Podgorica, Montenegro.
Summary
Combined analysis of E-cadherin and CD105 expression in laryngeal cancer can identify patients at high risk for recurrence. This approach helps predict aggressive tumor behavior and poor prognosis in laryngeal squamous cell carcinoma patients.
Area of Science:
- Oncology
- Pathology
- Cancer Biomarkers
Background:
- Laryngeal squamous cell carcinoma (LSCC) prognosis is influenced by tumor biology.
- Epithelial-mesenchymal transition (EMT) and angiogenesis are critical in cancer progression.
- E-cadherin (EMT marker) and CD105 (angiogenesis marker) roles in LSCC require further elucidation.
Purpose of the Study:
- To investigate the clinicopathologic significance of combined E-cadherin and CD105 immunohistochemical expression in LSCC.
- To assess the correlation between E-cadherin and CD105 expression levels.
- To determine if combined marker expression predicts tumor aggressiveness and patient outcomes.
Main Methods:
- Immunohistochemistry was used to assess E-cadherin and CD105 expression in 85 LSCC patient samples.
- Receiver operating curve (ROC) analysis determined cut-off values for high/low marker expression.
- Kaplan-Meier and Spearman's correlation analyses evaluated prognostic value and marker correlation.
Main Results:
- A high-risk group (CD105 high, E-cadherin low) correlated with younger age, advanced T-status, and higher TNM stage.
- The high-risk group showed a significantly higher rate of locoregional recurrence.
- Kaplan-Meier analysis indicated significantly worse prognosis for the high-risk group (p=0.024).
- Spearman's analysis revealed a non-significant negative correlation between E-cadherin and CD105 expression (p=0.505).
Conclusions:
- Combined E-cadherin and CD105 expression serves as a simple panel for identifying aggressive LSCC phenotypes.
- This marker combination predicts a higher risk of disease recurrence in laryngeal cancer patients.
- The findings support the use of these markers for risk stratification and personalized treatment strategies.
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