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Relationship between Compound α-Ketoacid and Microinflammation in Patients with Chronic Kidney Disease
Zaobin Chen1, Yongda Lin1, Jiali Wang1
1Department of Nephrology, The Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China.
Insights
Compound alpha-ketoacid supplementation can significantly improve the microinflammatory state in chronic kidney disease (CKD) patients. This intervention aids in reducing inflammation, improving nutritional status, and supporting overall kidney health.
Area of Science:
- Nephrology
- Biochemistry
- Nutritional Science
Background:
- Chronic kidney disease (CKD) is characterized by kidney structural or functional abnormalities lasting over 3 months.
- CKD is a major cause of global mortality and a significant risk factor for cardiovascular disease.
- Persistent microinflammation is a key factor in CKD progression, leading to renal fibrosis and function loss.
Purpose of the Study:
- To explore the relationship between compound alpha-ketoacid and microinflammation in CKD patients.
- To elucidate the mechanisms by which compound alpha-ketoacid may alleviate CKD-associated microinflammation.
Main Methods:
- This review synthesizes existing research on compound alpha-ketoacid's effects in CKD.
- Analysis focuses on compound alpha-ketoacid's impact on metabolic waste, inflammation, and oxidative stress.
Main Results:
- Compound alpha-ketoacid binds and promotes excretion of nitrogen-containing metabolites, reducing waste.
- It alleviates gastrointestinal issues and reduces oxidative stress and inflammatory responses.
- Compound alpha-ketoacid provides essential amino acids for CKD patients, improving nutritional status.
Conclusions:
- Compound alpha-ketoacid can improve the microinflammatory state in CKD.
- Benefits include improved nutritional status, acid-base balance, gut microbiota, and lipid metabolism.
- It offers a potential therapeutic strategy for managing inflammation in chronic kidney disease.
Abstract:
Chronic kidney disease (CKD) refers to the presence of structural or functional abnormalities in the kidneys that affect health, lasting for more than 3 months. CKD is not only the direct cause of global incidence rate and mortality, but also an important risk factor for cardiovascular disease. Persistent microinflammatory state has been recognized as an important component of CKD, which can lead to renal fibrosis and loss of renal function, and plays a crucial role in the pathophysiology and progression of the disease. Simultaneously, compound α-Ketoacid can bind nitrogen-containing metabolites in the blood and accelerate their excretion from the body, thereby reducing the level of metabolic waste, alleviating gastrointestinal reactions in patients, and reducing the inflammatory response and oxidative stress state of the body. Compound α-Ketoacid contains amino acids required by CKD patients. In this review, we explore the relationship between compound α-Ketoacid and microinflammation in patients with CKD. The review indicated that compound α-Ketoacid can improve the microinflammatory state in CKD patients by improving the nutritional status of CKD patients, improving patient's acid-base balance disorder, regulating oxidative stress, improving gut microbiota, and regulating abnormal lipid metabolism.
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