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Updated: Jul 1, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Photoinduced Decarboxylative Borylation of N-Hydroxyphthalimide Esters with Hypoboric Acid
Bálint Nagy1, Zsombor Gonda1,2, Tamás Földesi1
1MTA-ELTE "Lendület" Catalysis and Organic Synthesis Research Group, Eötvös Loránd University, Institute of Chemistry, Pázmány Péter stny. 1/A, H-1117 Budapest, Hungary.
Abstract:
We developed a visible-light-driven photochemical transformation in which activated primary, secondary, and tertiary alkylcarboxylic acids were converted into the corresponding boronic esters in the absence of catechol and any added photocatalyst. The procedure relies on the utilization of hypoboric acid and redox-active esters of alkylcarboxylic acids to ensure a simple and economic procedure. Quantum chemical calculations and mechanistic considerations provide deeper insights into the mechanism of photochemical borylation reactions.
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