Time trends in liver cancer mortality rates in Montenegro from 1990 to 2018

  • 0Department of Health Statistics, Center for Health System Evidence and Research in Public Health, Institute for Public Health of Montenegro.

Summary

This summary is machine-generated.

Liver cancer mortality rates remained stable in Montenegro from 1990-2018, despite an increase in cases, particularly among women. Prevention efforts may have contributed to this trend, with a focus on the elderly being crucial.

Area Of Science

  • Hepatology
  • Public Health
  • Epidemiology

Background

  • Liver cancer is a leading cause of cancer mortality globally, with viral hepatitis B and C as primary risk factors.
  • Montenegro has implemented viral hepatitis eradication strategies aligned with global initiatives to reduce liver cancer deaths.

Purpose Of The Study

  • To analyze liver cancer mortality trends in Montenegro between 1990 and 2018.
  • To evaluate the impact of public health interventions on liver cancer mortality patterns.

Main Methods

  • Utilized age-standardized liver cancer mortality data for Montenegro (1990-2018).
  • Employed joinpoint, linear, and Poisson regression analyses for trend assessment.
  • Conducted both overall and gender-specific trend analyses.

Main Results

  • Overall liver cancer mortality rates showed no significant trend, remaining constant.
  • A significant annual increase in liver cancer cases was observed (1.4% overall, 1.9% in women).
  • The 55-84 age groups represented the most affected populations by liver cancer mortality.

Conclusions

  • Consistent prevention and treatment of hepatitis infections appear to have stabilized liver cancer mortality rates.
  • Continued monitoring of guidelines and targeted attention to the elderly population are recommended for managing liver cancer.
  • Public health initiatives have shown partial success in mitigating liver cancer mortality in Montenegro.

Related Concept Videos

Diseases of the Liver and Gallbladder 01:26

535

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

Cancer Survival Analysis 01:21

345

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...

Hepatic Drug Excretion: Influencing Factors 01:16

128

The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...

Gross Anatomy of the Liver 01:17

426

The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...

mTOR Signaling and Cancer Progression 03:03

3.8K

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Liver Regeneration 01:24

3.3K

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...