Prevalence, trends, and characteristics of metabolic dysfunction-associated steatotic liver disease among the US population aged 12-79 years
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View abstract on PubMed
Summary
This summary is machine-generated.Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence increased in US adults but remained stable in adolescents and young adults (AYA). Health providers should address MASLD risk factors and rising trends.
Area Of Science
- Hepatology
- Public Health
- Epidemiology
Background
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized in adults and adolescents and young adults (AYA).
- Prevalence trends and subgroup characteristics of MASLD remain unclear.
- Understanding these trends is crucial for targeted public health interventions.
Purpose Of The Study
- To evaluate the prevalence trend of MASLD in US adults and AYA from 1999 to 2018.
- To identify demographic and clinical characteristics associated with high MASLD prevalence.
- To inform public health strategies for MASLD prevention and management.
Main Methods
- Cross-sectional study using National Health and Nutrition Examination Survey (NHANES) data (1999-2018).
- Defined MASLD using US Fatty Liver Index (adults) and ALT elevation/obesity (AYA).
- Employed Joinpoint and logistic regression to analyze prevalence trends and associated factors.
Main Results
- MASLD prevalence increased significantly in US adults (30.8% to 37.7%) and specific subgroups (females, 20-45 & 61-79 years, non-Hispanic white).
- MASLD prevalence remained stable in AYA overall (5.1% to 5.2%) but increased in Mexican Americans.
- Adult MASLD associated with male sex, Mexican American ethnicity, age >50, poverty, poor health, obesity, and chronic conditions; AYA MASLD associated with male sex, poverty, and education.
Conclusions
- MASLD prevalence is rising in US adults, necessitating increased awareness and targeted interventions.
- Specific subgroups show varying MASLD prevalence trends, highlighting the need for tailored approaches.
- Healthcare providers should focus on preventing and treating MASLD-associated conditions and educating the public on its increasing prevalence.
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