Related Experiment Video

Updated: Jul 1, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

300

LncRNAs in necroptosis: Deciphering their role in cancer pathogenesis and therapy

Rahamat Unissa Syed1, S Afsar2, Nayla Ahmed Mohammed Aboshouk3

  • 1Department of Pharmaceutics, College of Pharmacy, University of Ha'il, Hail 81442, Saudi Arabia.

Pathology, Research and Practice
|March 13, 2024
PubMed

Insights

Long noncoding RNAs (lncRNAs) regulate necroptosis, a cell death pathway implicated in cancer. Targeting lncRNAs offers a promising strategy for developing novel cancer therapies by modulating necroptosis.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cell Death Mechanisms

Background:

  • Necroptosis is a regulated form of cell death distinct from apoptosis, increasingly recognized for its role in cancer development.
  • Long noncoding RNAs (lncRNAs) are emerging as critical regulators of diverse biological processes, including cell death pathways.
  • Understanding the interplay between lncRNAs and necroptosis is crucial for cancer biology and therapeutic development.

Purpose of the Study:

  • To investigate the intricate interactions between lncRNAs and key necroptosis effectors, namely mixed lineage kinase domain-like pseudokinase (MLKL) and receptor-interacting protein kinase 3 (RIPK3).
  • To elucidate the diverse mechanisms by which lncRNAs modulate necroptosis, including protein-protein interactions, transcriptional, and post-transcriptional regulation.
  • To explore the dual role of lncRNAs as tumor suppressors and oncogenes in cancer by influencing necroptotic pathways.

Main Methods:

  • Review of existing literature on lncRNA-necroptosis interactions in cancer.
  • Analysis of molecular mechanisms governing lncRNA regulation of MLKL and RIPK3.
  • Examination of lncRNA deregulation in various cancer types and its impact on necroptosis.

Main Results:

  • LncRNAs can influence necroptosis through direct interactions with MLKL and RIPK3, affecting their activation and downstream signaling.
  • Aberrant expression of specific lncRNAs is observed in cancers, correlating with altered necroptotic responses.
  • LncRNAs exhibit context-dependent roles, acting as either tumor suppressors or oncogenes in cancer progression via necroptosis modulation.

Conclusions:

  • LncRNAs play a complex and significant role in regulating necroptotic pathways, impacting cancer initiation and progression.
  • Targeting lncRNAs involved in necroptosis presents a viable therapeutic avenue for cancer treatment, potentially enhancing treatment efficacy and preventing metastasis.
  • LncRNA-based therapeutic strategies hold promise for controlling necroptosis and combating cancer effectively.
Keywords:
CancerLncRNAsMolecular effectorsNecroptosisTherapeutic strategies

More Related Videos

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

6.8K
Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis08:55

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis

Published on: August 7, 2018

10.9K

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
4.5K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.5K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
6.4K
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.9K