Dual checkpoint T(h1)eamwork makes the anti-cancer dream work
Alisa Dietl1, Anna Ralser1, Karin Pelka2
1Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Abstract:
Combined anti-PD-L1+anti-CTLA-4 therapy has shown benefits over anti-PD-L1 monotherapy as a neoadjuvant treatment in head and neck cancer. In this issue of Immunity, Franken et al. report that CD4+ T cell trafficking from lymph nodes to tumors and expansion toward T helper 1 cells are features specific to combination therapy.
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