Diagnostic Accuracy of a Combination of Preoperative 68-Ga Prostate-Specific Membrane Antigen Positron Emission...

Area of Science:

• Oncology
• Radiology
• Nuclear Medicine

Background:

• Prostate cancer (PCa) is a leading cause of cancer death in men.
• Multiparametric MRI (MpMRI) shows promise for PCa detection but has limitations.
• 68Ga PSMA I&T-PET/CT is an emerging alternative imaging modality for PCa.

Purpose of the Study:

• To compare the diagnostic accuracy of 68Ga PSMA I&T-PET/CT and MpMRI for prostate cancer tumor localization.
• To evaluate the efficacy of a combined imaging approach.

Main Methods:

• Retrospective analysis of preoperative MpMRI and 68Ga PSMA I&T-PET/CT scans.
• Comparison of imaging results with histopathological data from radical prostatectomy specimens.
• Evaluation of tumor localization accuracy for individual and combined imaging techniques.

Main Results:

• MpMRI achieved an accuracy of 75.9% (κ=0.525).
• 68Ga PSMA I&T-PET/CT showed an accuracy of 71.5% (κ=0.438).
• The combined imaging approach yielded the highest accuracy at 79.2% (κ=0.576), particularly in intermediate ISUP groups. SUVmax was 6.37.

Conclusions:

• Combined 68Ga PSMA I&T-PET/CT and MpMRI demonstrate high diagnostic rates for PCa tumor localization.
• The significant cost of combined imaging is a barrier to its routine clinical application.